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LIST OF ABBREVIATIONS

CHO

Chinese hamster ovary

CQA

Critical quality attribute

DLS

Dynamic light scattering

ELISA

Enzyme-linked immunosorbent assay

EMA

European Medicament Agency

FDA

Food and Drug Administration

IEX-HPLC Ion-exchange high performance liquid chromatography

IVP

Infectious viral particle

LC-MS

Mass spectrometry following liquid chromatography separation

NSTEM Negative staining transmission electron microscopy

NTA

Nanoparticle tracking analysis

PAT

Process analytical technology

Pfu

Plaque forming unit

QbD

Quality by design

RBC

Red blood cells

SPR

Surface plasmon resonance

SRID

Single radial immuno diffusion assay

TCID50 Tissue culture infectious Dose 50

TRPS

Tunable resistive pulse sensing technique

TU

Transducing unit

VLP

Virus-like particle

VP

Viral particle

224

Bioprocessing of Viral Vaccines